Articles
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Cardiovascular & Fluid Dynamics
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A multi-omics longitudinal study of the murine retinal response to chronic low-dose irradiation and simulated microgravity.
A multi-omics longitudinal study of the murine retinal response to chronic low-dose irradiation and simulated microgravity.
Cardiovascular & Fluid Dynamics
Abstractive Summary
Study examining a multi-omics longitudinal study of the murine retinal. Exposure to cosmic radiation causes substantial DNA damage and oxidative stress, with repair mechanisms partially effective. Cell cycle checkpoints and apoptosis are activated, but long-term cancer risk remains elevated at 3-5% for Mars missions. Effective radiation countermeasures are critical for deep space exploration.
Extractive Summary
Study examining a multi-omics longitudinal study of the murine retinal. Cosmic radiation exposure caused significant DNA damage with increased double-strand breaks. Cellular repair mechanisms were partially effective but overwhelmed at higher doses. Oxidative stress markers were elevated substantially. Cell cycle checkpoints showed prolonged activation. Apoptosis rates increased dose-dependently. Long-term cancer risk estimates ranged from 3-5% for Mars missions.
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Keywords
multi, omics, longitudinal, study, murine, retinal, response, chronic, dose, irradiation, study, increased, examining, multi, omics, longitudinal, murine, retinal, cosmic, radiation, study, radiation, effective, examining, multi, omics, longitudinal, murine, retinal, exposure
Abstractive Keywords
study, radiation, effective, examining, multi, omics, longitudinal, murine, retinal, exposure
Extractive Keywords
study, increased, examining, multi, omics, longitudinal, murine, retinal, cosmic, radiation
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