Articles
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Metabolism & Nutrition
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Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents
Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents
Metabolism & Nutrition
Abstractive Summary
Study examining cortical thinning and structural bone changes in non-human. Extended spaceflight causes significant bone loss through increased osteoclast activity and decreased osteoblast function. Calcium metabolism is disrupted, with elevated resorption markers. While countermeasures provide partial protection, complete recovery requires 12-18 months post-flight, presenting major challenges for long-duration missions.
Extractive Summary
Study examining cortical thinning and structural bone changes in non-human. Bone mineral density decreased significantly during extended spaceflight missions. Osteoclast activity increased while osteoblast function declined. Calcium metabolism was disrupted with elevated urinary calcium excretion. Bone resorption markers TRAP and CTX-1 were significantly elevated. Mechanical loading countermeasures showed partial effectiveness. Recovery of bone density post-flight required 12-18 months on average.
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Keywords
cortical, thinning, structural, bone, changes, human, primates, after, single, fraction, bone, density, significantly, calcium, elevated, study, examining, cortical, thinning, structural, bone, study, examining, cortical, thinning, structural, changes, human, extended, spaceflight
Abstractive Keywords
bone, study, examining, cortical, thinning, structural, changes, human, extended, spaceflight
Extractive Keywords
bone, density, significantly, calcium, elevated, study, examining, cortical, thinning, structural
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