Articles
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Metabolism & Nutrition
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Adaptation to space conditions of novel bacterial species isolated from the International Space Station revealed by functional gene annotations and comparative genome analysis
Adaptation to space conditions of novel bacterial species isolated from the International Space Station revealed by functional gene annotations and comparative genome analysis
Metabolism & Nutrition
Abstractive Summary
Study examining phylogenomics, phenotypic, and functional traits of five novel. Spaceflight triggers widespread changes in gene expression affecting stress responses, DNA repair, and mitochondrial function. Epigenetic modifications occur, with some changes persisting long after return. Understanding these molecular adaptations is fundamental to developing effective countermeasures for long-duration missions.
Extractive Summary
Study examining phylogenomics, phenotypic, and functional traits of five novel. Genome-wide expression analysis revealed thousands of differentially expressed genes. Stress response pathways were universally upregulated. DNA repair genes showed increased expression. Mitochondrial genes were downregulated substantially. Epigenetic modifications included altered methylation patterns. Some changes persisted months after return to Earth. Cell cycle regulation genes were significantly affected.
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Keywords
phylogenomics, phenotypic, functional, traits, five, novel, earth, derived, bacterial, species, genes, expression, study, examining, phylogenomics, phenotypic, functional, traits, five, novel, changes, long, study, examining, phylogenomics, phenotypic, functional, traits, five, novel
Abstractive Keywords
changes, long, study, examining, phylogenomics, phenotypic, functional, traits, five, novel
Extractive Keywords
genes, expression, study, examining, phylogenomics, phenotypic, functional, traits, five, novel
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