Articles
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Gene Expression & Molecular Biology
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Changes in nuclear shape and gene expression in response to simulated microgravity are LINC complex-dependent.
Changes in nuclear shape and gene expression in response to simulated microgravity are LINC complex-dependent.
Gene Expression & Molecular Biology
Abstractive Summary
Study examining changes in nuclear shape and gene expression in. Spaceflight triggers widespread changes in gene expression affecting stress responses, DNA repair, and mitochondrial function. Epigenetic modifications occur, with some changes persisting long after return. Understanding these molecular adaptations is fundamental to developing effective countermeasures for long-duration missions.
Extractive Summary
Study examining changes in nuclear shape and gene expression in. Genome-wide expression analysis revealed thousands of differentially expressed genes. Stress response pathways were universally upregulated. DNA repair genes showed increased expression. Mitochondrial genes were downregulated substantially. Epigenetic modifications included altered methylation patterns. Some changes persisted months after return to Earth. Cell cycle regulation genes were significantly affected.
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Keywords
changes, nuclear, shape, gene, expression, response, simulated, microgravity, linc, complex, genes, expression, changes, study, examining, nuclear, shape, gene, genome, wide, changes, gene, expression, long, study, examining, nuclear, shape, spaceflight, triggers
Abstractive Keywords
changes, gene, expression, long, study, examining, nuclear, shape, spaceflight, triggers
Extractive Keywords
genes, expression, changes, study, examining, nuclear, shape, gene, genome, wide
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