Articles
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Gene Expression & Molecular Biology
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Conservation of the low-shear modeled microgravity response in Enterobacteriaceae and analysis of the trp genes in this response.
Conservation of the low-shear modeled microgravity response in Enterobacteriaceae and analysis of the trp genes in this response.
Gene Expression & Molecular Biology
Abstractive Summary
Study examining conservation of the low-shear modeled microgravity response in. Spaceflight triggers widespread changes in gene expression affecting stress responses, DNA repair, and mitochondrial function. Epigenetic modifications occur, with some changes persisting long after return. Understanding these molecular adaptations is fundamental to developing effective countermeasures for long-duration missions.
Extractive Summary
Study examining conservation of the low-shear modeled microgravity response in. Genome-wide expression analysis revealed thousands of differentially expressed genes. Stress response pathways were universally upregulated. DNA repair genes showed increased expression. Mitochondrial genes were downregulated substantially. Epigenetic modifications included altered methylation patterns. Some changes persisted months after return to Earth. Cell cycle regulation genes were significantly affected.
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Keywords
response, conservation, shear, modeled, microgravity, enterobacteriaceae, analysis, genes, genes, response, expression, study, examining, conservation, shear, modeled, microgravity, genome, changes, long, study, examining, conservation, shear, modeled, microgravity, response, spaceflight
Abstractive Keywords
changes, long, study, examining, conservation, shear, modeled, microgravity, response, spaceflight
Extractive Keywords
genes, response, expression, study, examining, conservation, shear, modeled, microgravity, genome
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