Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction
Cardiovascular & Fluid Dynamics
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Study examining cosmic kidney disease: an integrated pan-omic, physiological and. Exposure to cosmic radiation causes substantial DNA damage and oxidative stress, with repair mechanisms partially effective. Cell cycle checkpoints and apoptosis are activated, but long-term cancer risk remains elevated at 3-5% for Mars missions. Effective radiation countermeasures are critical for deep space exploration.
Study examining cosmic kidney disease: an integrated pan-omic, physiological and. Cosmic radiation exposure caused significant DNA damage with increased double-strand breaks. Cellular repair mechanisms were partially effective but overwhelmed at higher doses. Oxidative stress markers were elevated substantially. Cell cycle checkpoints showed prolonged activation. Apoptosis rates increased dose-dependently. Long-term cancer risk estimates ranged from 3-5% for Mars missions.