Articles
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Cardiovascular & Fluid Dynamics
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Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction
Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction
Cardiovascular & Fluid Dynamics
Abstractive Summary
Study examining cosmic kidney disease: an integrated pan-omic, physiological and. Exposure to cosmic radiation causes substantial DNA damage and oxidative stress, with repair mechanisms partially effective. Cell cycle checkpoints and apoptosis are activated, but long-term cancer risk remains elevated at 3-5% for Mars missions. Effective radiation countermeasures are critical for deep space exploration.
Extractive Summary
Study examining cosmic kidney disease: an integrated pan-omic, physiological and. Cosmic radiation exposure caused significant DNA damage with increased double-strand breaks. Cellular repair mechanisms were partially effective but overwhelmed at higher doses. Oxidative stress markers were elevated substantially. Cell cycle checkpoints showed prolonged activation. Apoptosis rates increased dose-dependently. Long-term cancer risk estimates ranged from 3-5% for Mars missions.
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Keywords
cosmic, kidney, disease, integrated, omic, physiological, morphological, study, into, spaceflight, cosmic, increased, study, examining, kidney, disease, integrated, omic, physiological, radiation, cosmic, radiation, effective, study, examining, kidney, disease, integrated, omic, physiological
Abstractive Keywords
cosmic, radiation, effective, study, examining, kidney, disease, integrated, omic, physiological
Extractive Keywords
cosmic, increased, study, examining, kidney, disease, integrated, omic, physiological, radiation
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