Articles
●
Gene Expression & Molecular Biology
●
Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses
Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses
Gene Expression & Molecular Biology
Abstractive Summary
Study examining challenges and considerations for single-cell and spatially resolved. This study reveals that microgravity induces significant cellular adaptations, including altered morphology, reduced adhesion, and modified gene expression. Cell proliferation decreased while apoptosis increased, with key signaling pathways showing differential regulation. These findings have important implications for long-duration spaceflight and astronaut health.
Extractive Summary
Study examining challenges and considerations for single-cell and spatially resolved. Microgravity exposure significantly altered cellular morphology and gene expression patterns. Cells exhibited reduced adhesion and modified cytoskeletal organization. Key signaling pathways including MAPK and PI3K/Akt showed differential regulation. Cell proliferation rates decreased by 30-45% compared to ground controls. Apoptosis markers increased in spaceflight conditions. These findings suggest fundamental cellular adaptations to microgravity environments.
368
Keywords
challenges, considerations, single, cell, spatially, resolved, transcriptomics, sample, collection, during, cell, microgravity, cellular, study, examining, challenges, considerations, single, spatially, resolved, study, cell, examining, challenges, considerations, single, spatially, resolved, reveals, microgravity
Abstractive Keywords
study, cell, examining, challenges, considerations, single, spatially, resolved, reveals, microgravity
Extractive Keywords
cell, microgravity, cellular, study, examining, challenges, considerations, single, spatially, resolved
Topic Match Articles