Articles
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Metabolism & Nutrition
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Draft Genome Sequences of Klebsiella Species Isolated from the International Space Station
Draft Genome Sequences of Klebsiella Species Isolated from the International Space Station
Metabolism & Nutrition
Abstractive Summary
Study examining draft genome sequences of enterobacteriales strains isolated from. Spaceflight triggers widespread changes in gene expression affecting stress responses, DNA repair, and mitochondrial function. Epigenetic modifications occur, with some changes persisting long after return. Understanding these molecular adaptations is fundamental to developing effective countermeasures for long-duration missions.
Extractive Summary
Study examining draft genome sequences of enterobacteriales strains isolated from. Genome-wide expression analysis revealed thousands of differentially expressed genes. Stress response pathways were universally upregulated. DNA repair genes showed increased expression. Mitochondrial genes were downregulated substantially. Epigenetic modifications included altered methylation patterns. Some changes persisted months after return to Earth. Cell cycle regulation genes were significantly affected.
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Keywords
draft, genome, sequences, enterobacteriales, strains, isolated, from, international, space, station, genes, genome, expression, study, examining, draft, sequences, enterobacteriales, strains, isolated, changes, long, study, examining, draft, genome, sequences, enterobacteriales, strains, isolated
Abstractive Keywords
changes, long, study, examining, draft, genome, sequences, enterobacteriales, strains, isolated
Extractive Keywords
genes, genome, expression, study, examining, draft, sequences, enterobacteriales, strains, isolated
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