Effects of low-dose rate Œ≥-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart

Cardiovascular & Fluid Dynamics

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cardiac, mass, blood, flight, study, examining, effects, dose, rate, irradiation

Study examining effects of low-dose rate œ≥-irradiation combined with simulated. Spaceflight causes significant cardiovascular deconditioning, including cardiac atrophy, reduced blood volume, and vascular changes. Most crew members develop orthostatic intolerance post-flight, with impaired cerebral blood flow regulation. Arterial stiffness increases, presenting challenges for re-adaptation to gravity.

Study examining effects of low-dose rate œ≥-irradiation combined with simulated. Cardiovascular deconditioning was observed with reduced cardiac mass and altered vascular function. Blood volume decreased by 10-15% within first weeks. Orthostatic intolerance developed in 70% of crew post-flight. Carotid artery stiffness increased during flight. Cardiac atrophy affected left ventricular mass. Cerebral blood flow regulation was impaired upon return to gravity.

‹ The Effect of spaceflight on mouse olfactory bulb volume, neurogenesis, and cell death indicates the protective effect of novel environment.

Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations. ›