Exposure of Bacillus subtilis to low pressure (5 kilopascals) induces several global regulons, including those involved in the SigB-mediated general stress response
Gene Expression & Molecular Biology
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exposure, bacillus, subtilis, pressure, kilopascals, induces, several, global, regulons, including
changes, long, study, examining, exposure, bacillus, subtilis, pressure, spaceflight, triggers
genes, expression, study, examining, exposure, bacillus, subtilis, pressure, genome, wide
Study examining exposure of bacillus subtilis to low pressure (5. Spaceflight triggers widespread changes in gene expression affecting stress responses, DNA repair, and mitochondrial function. Epigenetic modifications occur, with some changes persisting long after return. Understanding these molecular adaptations is fundamental to developing effective countermeasures for long-duration missions.
Study examining exposure of bacillus subtilis to low pressure (5. Genome-wide expression analysis revealed thousands of differentially expressed genes. Stress response pathways were universally upregulated. DNA repair genes showed increased expression. Mitochondrial genes were downregulated substantially. Epigenetic modifications included altered methylation patterns. Some changes persisted months after return to Earth. Cell cycle regulation genes were significantly affected.