Articles
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Metabolism & Nutrition
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Genomic analysis reveals the presence of emerging pathogenic Klebsiella lineages aboard the International Space Station
Genomic analysis reveals the presence of emerging pathogenic Klebsiella lineages aboard the International Space Station
Metabolism & Nutrition
Abstractive Summary
Study examining characterization of metagenome-assembled genomes from the international space. Spaceflight triggers widespread changes in gene expression affecting stress responses, DNA repair, and mitochondrial function. Epigenetic modifications occur, with some changes persisting long after return. Understanding these molecular adaptations is fundamental to developing effective countermeasures for long-duration missions.
Extractive Summary
Study examining characterization of metagenome-assembled genomes from the international space. Genome-wide expression analysis revealed thousands of differentially expressed genes. Stress response pathways were universally upregulated. DNA repair genes showed increased expression. Mitochondrial genes were downregulated substantially. Epigenetic modifications included altered methylation patterns. Some changes persisted months after return to Earth. Cell cycle regulation genes were significantly affected.
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Keywords
characterization, metagenome, assembled, genomes, from, international, space, station, genes, expression, study, examining, characterization, metagenome, assembled, genomes, from, international, changes, long, study, examining, characterization, metagenome, assembled, genomes, from, international
Abstractive Keywords
changes, long, study, examining, characterization, metagenome, assembled, genomes, from, international
Extractive Keywords
genes, expression, study, examining, characterization, metagenome, assembled, genomes, from, international
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