Genomic, functional, and metabolic enhancements in multidrug-resistant Enterobacter bugandensis facilitating its persistence and succession in the International Space Station
Metabolism & Nutrition
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genomic, analysis, reveals, presence, emerging, pathogenic, klebsiella, lineages, aboard, international
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genes, analysis, expression, study, examining, genomic, reveals, presence, emerging, pathogenic
Study examining genomic analysis reveals the presence of emerging pathogenic. Spaceflight triggers widespread changes in gene expression affecting stress responses, DNA repair, and mitochondrial function. Epigenetic modifications occur, with some changes persisting long after return. Understanding these molecular adaptations is fundamental to developing effective countermeasures for long-duration missions.
Study examining genomic analysis reveals the presence of emerging pathogenic. Genome-wide expression analysis revealed thousands of differentially expressed genes. Stress response pathways were universally upregulated. DNA repair genes showed increased expression. Mitochondrial genes were downregulated substantially. Epigenetic modifications included altered methylation patterns. Some changes persisted months after return to Earth. Cell cycle regulation genes were significantly affected.