Articles
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Gene Expression & Molecular Biology
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Growth and antifungal resistance of the pathogenic yeast, Candida albicans, in the microgravity environment of the International Space Station: An aggregate of multiple flight experiences.
Growth and antifungal resistance of the pathogenic yeast, Candida albicans, in the microgravity environment of the International Space Station: An aggregate of multiple flight experiences.
Gene Expression & Molecular Biology
Abstractive Summary
Study examining growth and antifungal resistance of the pathogenic yeast,. Spaceflight triggers widespread changes in gene expression affecting stress responses, DNA repair, and mitochondrial function. Epigenetic modifications occur, with some changes persisting long after return. Understanding these molecular adaptations is fundamental to developing effective countermeasures for long-duration missions.
Extractive Summary
Study examining growth and antifungal resistance of the pathogenic yeast,. Genome-wide expression analysis revealed thousands of differentially expressed genes. Stress response pathways were universally upregulated. DNA repair genes showed increased expression. Mitochondrial genes were downregulated substantially. Epigenetic modifications included altered methylation patterns. Some changes persisted months after return to Earth. Cell cycle regulation genes were significantly affected.
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Keywords
growth, antifungal, resistance, pathogenic, yeast, candida, albicans, microgravity, environment, international, genes, expression, study, examining, growth, antifungal, resistance, pathogenic, yeast, genome, changes, long, study, examining, growth, antifungal, resistance, pathogenic, yeast, spaceflight
Abstractive Keywords
changes, long, study, examining, growth, antifungal, resistance, pathogenic, yeast, spaceflight
Extractive Keywords
genes, expression, study, examining, growth, antifungal, resistance, pathogenic, yeast, genome
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