Articles
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Plant Biology & Bioregenerative Systems
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Inhibition of SARS-CoV-2 wild-type (Wuhan-Hu-1) and Delta (B.1.617.2) strains by marine sulfated glycans.
Inhibition of SARS-CoV-2 wild-type (Wuhan-Hu-1) and Delta (B.1.617.2) strains by marine sulfated glycans.
Plant Biology & Bioregenerative Systems
Abstractive Summary
Study examining safety and pharmacokinetics of intranasally administered heparin. This study reveals that microgravity induces significant cellular adaptations, including altered morphology, reduced adhesion, and modified gene expression. Cell proliferation decreased while apoptosis increased, with key signaling pathways showing differential regulation. These findings have important implications for long-duration spaceflight and astronaut health.
Extractive Summary
Study examining safety and pharmacokinetics of intranasally administered heparin. Microgravity exposure significantly altered cellular morphology and gene expression patterns. Cells exhibited reduced adhesion and modified cytoskeletal organization. Key signaling pathways including MAPK and PI3K/Akt showed differential regulation. Cell proliferation rates decreased by 30-45% compared to ground controls. Apoptosis markers increased in spaceflight conditions. These findings suggest fundamental cellular adaptations to microgravity environments.
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Keywords
safety, pharmacokinetics, intranasally, administered, heparin, microgravity, cellular, study, examining, safety, pharmacokinetics, intranasally, administered, heparin, exposure, study, examining, safety, pharmacokinetics, intranasally, administered, heparin, reveals, microgravity, induces
Abstractive Keywords
study, examining, safety, pharmacokinetics, intranasally, administered, heparin, reveals, microgravity, induces
Extractive Keywords
microgravity, cellular, study, examining, safety, pharmacokinetics, intranasally, administered, heparin, exposure
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