Articles
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Gene Expression & Molecular Biology
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Is spaceflight-induced immune dysfunction linked to systemic changes in metabolism?
Is spaceflight-induced immune dysfunction linked to systemic changes in metabolism?
Gene Expression & Molecular Biology
Abstractive Summary
Study examining changes in the distribution and function of leukocytes. Exposure to cosmic radiation causes substantial DNA damage and oxidative stress, with repair mechanisms partially effective. Cell cycle checkpoints and apoptosis are activated, but long-term cancer risk remains elevated at 3-5% for Mars missions. Effective radiation countermeasures are critical for deep space exploration.
Extractive Summary
Study examining changes in the distribution and function of leukocytes. Cosmic radiation exposure caused significant DNA damage with increased double-strand breaks. Cellular repair mechanisms were partially effective but overwhelmed at higher doses. Oxidative stress markers were elevated substantially. Cell cycle checkpoints showed prolonged activation. Apoptosis rates increased dose-dependently. Long-term cancer risk estimates ranged from 3-5% for Mars missions.
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Keywords
changes, distribution, function, leukocytes, after, whole, body, iron, irradiation, increased, study, examining, changes, distribution, function, leukocytes, cosmic, radiation, exposure, radiation, effective, study, examining, changes, distribution, function, leukocytes, exposure, cosmic
Abstractive Keywords
radiation, effective, study, examining, changes, distribution, function, leukocytes, exposure, cosmic
Extractive Keywords
increased, study, examining, changes, distribution, function, leukocytes, cosmic, radiation, exposure
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