Lab-on-a-chip approaches for space-biology research.
Plant Biology & Bioregenerative Systems
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Study examining multi-analyte biochip (mab) based on all-solid-state ion-selective electrodes. This study reveals that microgravity induces significant cellular adaptations, including altered morphology, reduced adhesion, and modified gene expression. Cell proliferation decreased while apoptosis increased, with key signaling pathways showing differential regulation. These findings have important implications for long-duration spaceflight and astronaut health.
Study examining multi-analyte biochip (mab) based on all-solid-state ion-selective electrodes. Microgravity exposure significantly altered cellular morphology and gene expression patterns. Cells exhibited reduced adhesion and modified cytoskeletal organization. Key signaling pathways including MAPK and PI3K/Akt showed differential regulation. Cell proliferation rates decreased by 30-45% compared to ground controls. Apoptosis markers increased in spaceflight conditions. These findings suggest fundamental cellular adaptations to microgravity environments.