Articles
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Cardiovascular & Fluid Dynamics
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Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight
Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight
Cardiovascular & Fluid Dynamics
Abstractive Summary
Study examining longitudinal multi-omics analysis of host microbiome architecture and. Space travel significantly compromises immune function through impaired T-cell activity, reduced NK cell function, and inflammatory cytokine dysregulation. Latent viruses frequently reactivate, and wound healing is delayed. These findings raise concerns about infection risk and vaccine effectiveness during long missions.
Extractive Summary
Study examining longitudinal multi-omics analysis of host microbiome architecture and. Spaceflight induced significant immune system dysregulation. T-cell function was impaired with reduced proliferation capacity. Natural killer cell activity decreased substantially. Cytokine profiles shifted toward pro-inflammatory states. Latent viral reactivation occurred in 60% of crew members. Wound healing processes were delayed. Vaccine efficacy may be compromised in space environments.
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Keywords
longitudinal, multi, omics, analysis, host, microbiome, architecture, immune, responses, during, cell, study, examining, longitudinal, multi, omics, analysis, host, microbiome, architecture, function, cell, study, examining, longitudinal, multi, omics, analysis, host, microbiome
Abstractive Keywords
function, cell, study, examining, longitudinal, multi, omics, analysis, host, microbiome
Extractive Keywords
cell, study, examining, longitudinal, multi, omics, analysis, host, microbiome, architecture
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