Articles
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Plant Biology & Bioregenerative Systems
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Longitudinal time course of muscle impairments during partial weight-bearing in rats
Longitudinal time course of muscle impairments during partial weight-bearing in rats
Plant Biology & Bioregenerative Systems
Abstractive Summary
Study examining structural and functional properties of bone are compromised. Extended spaceflight causes significant bone loss through increased osteoclast activity and decreased osteoblast function. Calcium metabolism is disrupted, with elevated resorption markers. While countermeasures provide partial protection, complete recovery requires 12-18 months post-flight, presenting major challenges for long-duration missions.
Extractive Summary
Study examining structural and functional properties of bone are compromised. Bone mineral density decreased significantly during extended spaceflight missions. Osteoclast activity increased while osteoblast function declined. Calcium metabolism was disrupted with elevated urinary calcium excretion. Bone resorption markers TRAP and CTX-1 were significantly elevated. Mechanical loading countermeasures showed partial effectiveness. Recovery of bone density post-flight required 12-18 months on average.
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Keywords
structural, functional, properties, bone, compromised, amyotrophic, lateral, sclerosis, mice, bone, density, significantly, calcium, elevated, study, examining, structural, functional, properties, bone, study, examining, structural, functional, properties, compromised, extended, spaceflight, causes
Abstractive Keywords
bone, study, examining, structural, functional, properties, compromised, extended, spaceflight, causes
Extractive Keywords
bone, density, significantly, calcium, elevated, study, examining, structural, functional, properties
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