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Cardiovascular & Fluid Dynamics

Mice Exposed to Combined Chronic Low-Dose Irradiation and Modeled Microgravity Develop Long-Term Neurological Sequelae.

Mice Exposed to Combined Chronic Low-Dose Irradiation and Modeled Microgravity Develop Long-Term Neurological Sequelae.

Cardiovascular & Fluid Dynamics

Abstractive Summary

Study examining mice exposed to combined chronic low-dose irradiation and. Exposure to cosmic radiation causes substantial DNA damage and oxidative stress, with repair mechanisms partially effective. Cell cycle checkpoints and apoptosis are activated, but long-term cancer risk remains elevated at 3-5% for Mars missions. Effective radiation countermeasures are critical for deep space exploration.

Extractive Summary

Study examining mice exposed to combined chronic low-dose irradiation and. Cosmic radiation exposure caused significant DNA damage with increased double-strand breaks. Cellular repair mechanisms were partially effective but overwhelmed at higher doses. Oxidative stress markers were elevated substantially. Cell cycle checkpoints showed prolonged activation. Apoptosis rates increased dose-dependently. Long-term cancer risk estimates ranged from 3-5% for Mars missions.

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Keywords

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Abstractive Keywords

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Extractive Keywords

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