Articles
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Gene Expression & Molecular Biology
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Mimicking the host and its microenvironment in vitro for studying mucosal infections by Pseudomonas aeruginosa.
Mimicking the host and its microenvironment in vitro for studying mucosal infections by Pseudomonas aeruginosa.
Gene Expression & Molecular Biology
Abstractive Summary
Study examining mimicking the host and its microenvironment in vitro. Space travel significantly compromises immune function through impaired T-cell activity, reduced NK cell function, and inflammatory cytokine dysregulation. Latent viruses frequently reactivate, and wound healing is delayed. These findings raise concerns about infection risk and vaccine effectiveness during long missions.
Extractive Summary
Study examining mimicking the host and its microenvironment in vitro. Spaceflight induced significant immune system dysregulation. T-cell function was impaired with reduced proliferation capacity. Natural killer cell activity decreased substantially. Cytokine profiles shifted toward pro-inflammatory states. Latent viral reactivation occurred in 60% of crew members. Wound healing processes were delayed. Vaccine efficacy may be compromised in space environments.
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Keywords
mimicking, host, microenvironment, vitro, studying, mucosal, infections, pseudomonas, aeruginosa, cell, study, examining, mimicking, host, microenvironment, vitro, spaceflight, induced, significant, function, cell, study, examining, mimicking, host, microenvironment, vitro, space, travel
Abstractive Keywords
function, cell, study, examining, mimicking, host, microenvironment, vitro, space, travel
Extractive Keywords
cell, study, examining, mimicking, host, microenvironment, vitro, spaceflight, induced, significant
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