Articles
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Gene Expression & Molecular Biology
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Resistance of Bacillus subtilis Spore DNA to Lethal Ionizing Radiation Damage Relies Primarily on Spore Core Components and DNA Repair, with Minor Effects of Oxygen Radical Detoxification
Resistance of Bacillus subtilis Spore DNA to Lethal Ionizing Radiation Damage Relies Primarily on Spore Core Components and DNA Repair, with Minor Effects of Oxygen Radical Detoxification
Gene Expression & Molecular Biology
Abstractive Summary
Study examining resistance of bacillus subtilis spore dna to lethal. Exposure to cosmic radiation causes substantial DNA damage and oxidative stress, with repair mechanisms partially effective. Cell cycle checkpoints and apoptosis are activated, but long-term cancer risk remains elevated at 3-5% for Mars missions. Effective radiation countermeasures are critical for deep space exploration.
Extractive Summary
Study examining resistance of bacillus subtilis spore dna to lethal. Cosmic radiation exposure caused significant DNA damage with increased double-strand breaks. Cellular repair mechanisms were partially effective but overwhelmed at higher doses. Oxidative stress markers were elevated substantially. Cell cycle checkpoints showed prolonged activation. Apoptosis rates increased dose-dependently. Long-term cancer risk estimates ranged from 3-5% for Mars missions.
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Keywords
spore, resistance, bacillus, subtilis, lethal, ionizing, radiation, damage, relies, primarily, increased, study, examining, resistance, bacillus, subtilis, spore, lethal, cosmic, radiation, radiation, effective, study, examining, resistance, bacillus, subtilis, spore, lethal, exposure
Abstractive Keywords
radiation, effective, study, examining, resistance, bacillus, subtilis, spore, lethal, exposure
Extractive Keywords
increased, study, examining, resistance, bacillus, subtilis, spore, lethal, cosmic, radiation
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