Articles
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Cardiovascular & Fluid Dynamics
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Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight
Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight
Cardiovascular & Fluid Dynamics
Abstractive Summary
Study examining single-cell analysis identifies conserved features of immune dysfunction. Space travel significantly compromises immune function through impaired T-cell activity, reduced NK cell function, and inflammatory cytokine dysregulation. Latent viruses frequently reactivate, and wound healing is delayed. These findings raise concerns about infection risk and vaccine effectiveness during long missions.
Extractive Summary
Study examining single-cell analysis identifies conserved features of immune dysfunction. Spaceflight induced significant immune system dysregulation. T-cell function was impaired with reduced proliferation capacity. Natural killer cell activity decreased substantially. Cytokine profiles shifted toward pro-inflammatory states. Latent viral reactivation occurred in 60% of crew members. Wound healing processes were delayed. Vaccine efficacy may be compromised in space environments.
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Keywords
single, cell, analysis, identifies, conserved, features, immune, dysfunction, simulated, microgravity, cell, immune, study, examining, single, analysis, identifies, conserved, features, dysfunction, cell, immune, function, study, examining, single, analysis, identifies, conserved, features
Abstractive Keywords
cell, immune, function, study, examining, single, analysis, identifies, conserved, features
Extractive Keywords
cell, immune, study, examining, single, analysis, identifies, conserved, features, dysfunction
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