Spaceflight-induced gene expression profiles in the mouse brain are attenuated by treatment with the antioxidant BuOE
Gene Expression & Molecular Biology
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Study examining transcriptomic effects on the mouse heart following 30. Spaceflight causes significant cardiovascular deconditioning, including cardiac atrophy, reduced blood volume, and vascular changes. Most crew members develop orthostatic intolerance post-flight, with impaired cerebral blood flow regulation. Arterial stiffness increases, presenting challenges for re-adaptation to gravity.
Study examining transcriptomic effects on the mouse heart following 30. Cardiovascular deconditioning was observed with reduced cardiac mass and altered vascular function. Blood volume decreased by 10-15% within first weeks. Orthostatic intolerance developed in 70% of crew post-flight. Carotid artery stiffness increased during flight. Cardiac atrophy affected left ventricular mass. Cerebral blood flow regulation was impaired upon return to gravity.