Telomeric RNA (TERRA) increases in response to spaceflight and high-altitude climbing
Cardiovascular & Fluid Dynamics
telomeric, terra, increases, response, spaceflight, high, altitude, climbing, genes, response, expression, study, examining, telomeric, terra, increases, spaceflight, genome, spaceflight, changes, long, study, examining, telomeric, terra, increases, response, triggers
telomeric, terra, increases, response, spaceflight, high, altitude, climbing
spaceflight, changes, long, study, examining, telomeric, terra, increases, response, triggers
genes, response, expression, study, examining, telomeric, terra, increases, spaceflight, genome
Study examining telomeric rna (terra) increases in response to spaceflight. Spaceflight triggers widespread changes in gene expression affecting stress responses, DNA repair, and mitochondrial function. Epigenetic modifications occur, with some changes persisting long after return. Understanding these molecular adaptations is fundamental to developing effective countermeasures for long-duration missions.
Study examining telomeric rna (terra) increases in response to spaceflight. Genome-wide expression analysis revealed thousands of differentially expressed genes. Stress response pathways were universally upregulated. DNA repair genes showed increased expression. Mitochondrial genes were downregulated substantially. Epigenetic modifications included altered methylation patterns. Some changes persisted months after return to Earth. Cell cycle regulation genes were significantly affected.