Articles
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Microbiome & Environmental Microbiology
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The smallest space miners: Principles of space biomining
The smallest space miners: Principles of space biomining
Microbiome & Environmental Microbiology
Abstractive Summary
Study examining overexpression of cupb5 activates alginate overproduction in pseudomonas. Spaceflight triggers widespread changes in gene expression affecting stress responses, DNA repair, and mitochondrial function. Epigenetic modifications occur, with some changes persisting long after return. Understanding these molecular adaptations is fundamental to developing effective countermeasures for long-duration missions.
Extractive Summary
Study examining overexpression of cupb5 activates alginate overproduction in pseudomonas. Genome-wide expression analysis revealed thousands of differentially expressed genes. Stress response pathways were universally upregulated. DNA repair genes showed increased expression. Mitochondrial genes were downregulated substantially. Epigenetic modifications included altered methylation patterns. Some changes persisted months after return to Earth. Cell cycle regulation genes were significantly affected.
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Keywords
overexpression, cupb5, activates, alginate, overproduction, pseudomonas, aeruginosa, novel, algw, dependent, genes, expression, study, examining, overexpression, cupb5, activates, alginate, overproduction, pseudomonas, changes, long, study, examining, overexpression, cupb5, activates, alginate, overproduction, pseudomonas
Abstractive Keywords
changes, long, study, examining, overexpression, cupb5, activates, alginate, overproduction, pseudomonas
Extractive Keywords
genes, expression, study, examining, overexpression, cupb5, activates, alginate, overproduction, pseudomonas
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