Articles
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Cardiovascular & Fluid Dynamics
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To boldly go where no microRNAs have gone before: Spaceflight impact on risk for small-for-gestational-age infants
To boldly go where no microRNAs have gone before: Spaceflight impact on risk for small-for-gestational-age infants
Cardiovascular & Fluid Dynamics
Abstractive Summary
Study examining to boldly go where no micrornas have gone. Spaceflight triggers widespread changes in gene expression affecting stress responses, DNA repair, and mitochondrial function. Epigenetic modifications occur, with some changes persisting long after return. Understanding these molecular adaptations is fundamental to developing effective countermeasures for long-duration missions.
Extractive Summary
Study examining to boldly go where no micrornas have gone. Genome-wide expression analysis revealed thousands of differentially expressed genes. Stress response pathways were universally upregulated. DNA repair genes showed increased expression. Mitochondrial genes were downregulated substantially. Epigenetic modifications included altered methylation patterns. Some changes persisted months after return to Earth. Cell cycle regulation genes were significantly affected.
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Keywords
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Abstractive Keywords
changes, long, study, examining, boldly, where, micrornas, gone, spaceflight, triggers
Extractive Keywords
genes, expression, study, examining, boldly, where, micrornas, gone, genome, wide
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