Transcriptome and proteome responses in RNAlater preserved tissue of Arabidopsis thaliana.
Metabolism & Nutrition
transcriptomics, pathway, potential, spaceflight, related, health, consequences, spaceflight, microgravity, cellular, study, examining, transcriptomics, pathway, potential, related, health, study, spaceflight, health, examining, transcriptomics, pathway, potential, related, reveals, microgravity
transcriptomics, pathway, potential, spaceflight, related, health, consequences
study, spaceflight, health, examining, transcriptomics, pathway, potential, related, reveals, microgravity
spaceflight, microgravity, cellular, study, examining, transcriptomics, pathway, potential, related, health
Study examining transcriptomics, nf-Ϻb pathway, and their potential spaceflight-related health. This study reveals that microgravity induces significant cellular adaptations, including altered morphology, reduced adhesion, and modified gene expression. Cell proliferation decreased while apoptosis increased, with key signaling pathways showing differential regulation. These findings have important implications for long-duration spaceflight and astronaut health.
Study examining transcriptomics, nf-Ϻb pathway, and their potential spaceflight-related health. Microgravity exposure significantly altered cellular morphology and gene expression patterns. Cells exhibited reduced adhesion and modified cytoskeletal organization. Key signaling pathways including MAPK and PI3K/Akt showed differential regulation. Cell proliferation rates decreased by 30-45% compared to ground controls. Apoptosis markers increased in spaceflight conditions. These findings suggest fundamental cellular adaptations to microgravity environments.