Articles
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Cellular & Tissue Engineering
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Absence of gamma-sarcoglycan alters the response of p70S6 kinase to mechanical perturbation in murine skeletal muscle
Absence of gamma-sarcoglycan alters the response of p70S6 kinase to mechanical perturbation in murine skeletal muscle
Cellular & Tissue Engineering
Abstractive Summary
Study examining absence of gamma-sarcoglycan alters the response of p70s6. Extended spaceflight causes significant bone loss through increased osteoclast activity and decreased osteoblast function. Calcium metabolism is disrupted, with elevated resorption markers. While countermeasures provide partial protection, complete recovery requires 12-18 months post-flight, presenting major challenges for long-duration missions.
Extractive Summary
Study examining absence of gamma-sarcoglycan alters the response of p70s6. Bone mineral density decreased significantly during extended spaceflight missions. Osteoclast activity increased while osteoblast function declined. Calcium metabolism was disrupted with elevated urinary calcium excretion. Bone resorption markers TRAP and CTX-1 were significantly elevated. Mechanical loading countermeasures showed partial effectiveness. Recovery of bone density post-flight required 12-18 months on average.
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Keywords
absence, gamma, sarcoglycan, alters, response, p70s6, kinase, mechanical, perturbation, murine, bone, density, significantly, calcium, elevated, study, examining, absence, gamma, sarcoglycan, study, examining, absence, gamma, sarcoglycan, alters, response, p70s6, extended, spaceflight
Abstractive Keywords
study, examining, absence, gamma, sarcoglycan, alters, response, p70s6, extended, spaceflight
Extractive Keywords
bone, density, significantly, calcium, elevated, study, examining, absence, gamma, sarcoglycan
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