Articles
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Cellular & Tissue Engineering
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Microgravity induces pelvic bone loss through osteoclastic activity, osteocytic osteolysis, and osteoblastic cell cycle inhibition by CDKN1a/p21
Microgravity induces pelvic bone loss through osteoclastic activity, osteocytic osteolysis, and osteoblastic cell cycle inhibition by CDKN1a/p21
Cellular & Tissue Engineering
Abstractive Summary
Microgravity exposure leads to significant bone loss in astronauts, particularly in weight-bearing bones. This study investigated the cellular mechanisms underlying pelvic bone loss. We found that microgravity increases osteoclastic activity while inhibiting osteoblastic function, leading to net bone resorption.
Extractive Summary
This study investigated the cellular mechanisms underlying pelvic bone loss in a murine model of spaceflight. Results Hindlimb unloading resulted in significant pelvic bone loss ( reduction in bone mineral density). Abstract Microgravity exposure leads to significant bone loss in astronauts, particularly in weight-bearing bones. Introduction Bone loss is one of the most significant health concerns for astronauts during long-duration spaceflight. Conclusion Microgravity-induced pelvic bone loss is primarily mediated by increased osteoclastic activity and decreased osteoblastic function.
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Keywords
microgravity, induces, pelvic, bone, loss, through, osteoclastic, activity, osteocytic, osteolysis, bone, loss, pelvic, significant, spaceflight, microgravity, astronauts, study, investigated, cellular, bone, microgravity, loss, exposure, leads, significant, astronauts, particularly, weight, bearing
Abstractive Keywords
bone, microgravity, loss, exposure, leads, significant, astronauts, particularly, weight, bearing
Extractive Keywords
bone, loss, pelvic, significant, spaceflight, microgravity, astronauts, study, investigated, cellular
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