Acute exposure to high dose gamma-radiation results in transient activation of bone lining cells
Neurological & Sensory System Changes
failure, generate, bone, marrow, adipocytes, protect, mice, from, ovariectomy, induced, bone, density, significantly, calcium, elevated, study, examining, failure, generate, marrow, bone, study, examining, failure, generate, marrow, adipocytes, extended, spaceflight, causes
failure, generate, bone, marrow, adipocytes, protect, mice, from, ovariectomy, induced
bone, study, examining, failure, generate, marrow, adipocytes, extended, spaceflight, causes
bone, density, significantly, calcium, elevated, study, examining, failure, generate, marrow
Study examining failure to generate bone marrow adipocytes does not. Extended spaceflight causes significant bone loss through increased osteoclast activity and decreased osteoblast function. Calcium metabolism is disrupted, with elevated resorption markers. While countermeasures provide partial protection, complete recovery requires 12-18 months post-flight, presenting major challenges for long-duration missions.
Study examining failure to generate bone marrow adipocytes does not. Bone mineral density decreased significantly during extended spaceflight missions. Osteoclast activity increased while osteoblast function declined. Calcium metabolism was disrupted with elevated urinary calcium excretion. Bone resorption markers TRAP and CTX-1 were significantly elevated. Mechanical loading countermeasures showed partial effectiveness. Recovery of bone density post-flight required 12-18 months on average.