Articles
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Immune System Function & Infection
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An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis
An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis
Immune System Function & Infection
Abstractive Summary
Study examining an extensive allelic series of drosophila kae1 mutants. Spaceflight triggers widespread changes in gene expression affecting stress responses, DNA repair, and mitochondrial function. Epigenetic modifications occur, with some changes persisting long after return. Understanding these molecular adaptations is fundamental to developing effective countermeasures for long-duration missions.
Extractive Summary
Study examining an extensive allelic series of drosophila kae1 mutants. Genome-wide expression analysis revealed thousands of differentially expressed genes. Stress response pathways were universally upregulated. DNA repair genes showed increased expression. Mitochondrial genes were downregulated substantially. Epigenetic modifications included altered methylation patterns. Some changes persisted months after return to Earth. Cell cycle regulation genes were significantly affected.
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Keywords
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Abstractive Keywords
changes, long, study, examining, extensive, allelic, series, drosophila, kae1, mutants
Extractive Keywords
genes, expression, study, examining, extensive, allelic, series, drosophila, kae1, mutants
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