Articles
●
Neurological & Sensory System Changes
●
Bone Marrow Adipose Tissue Deficiency Increases Disuse-Induced Bone Loss in Male Mice
Bone Marrow Adipose Tissue Deficiency Increases Disuse-Induced Bone Loss in Male Mice
Neurological & Sensory System Changes
Abstractive Summary
Study examining leptin stimulates bone formation in ob/ob mice at. Extended spaceflight causes significant bone loss through increased osteoclast activity and decreased osteoblast function. Calcium metabolism is disrupted, with elevated resorption markers. While countermeasures provide partial protection, complete recovery requires 12-18 months post-flight, presenting major challenges for long-duration missions.
Extractive Summary
Study examining leptin stimulates bone formation in ob/ob mice at. Bone mineral density decreased significantly during extended spaceflight missions. Osteoclast activity increased while osteoblast function declined. Calcium metabolism was disrupted with elevated urinary calcium excretion. Bone resorption markers TRAP and CTX-1 were significantly elevated. Mechanical loading countermeasures showed partial effectiveness. Recovery of bone density post-flight required 12-18 months on average.
472
Keywords
leptin, stimulates, bone, formation, mice, doses, having, minimal, impact, energy, bone, density, significantly, calcium, elevated, study, examining, leptin, stimulates, formation, bone, study, examining, leptin, stimulates, formation, mice, extended, spaceflight, causes
Abstractive Keywords
bone, study, examining, leptin, stimulates, formation, mice, extended, spaceflight, causes
Extractive Keywords
bone, density, significantly, calcium, elevated, study, examining, leptin, stimulates, formation
Topic Match Articles