Articles
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Cellular & Tissue Engineering
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Characterization of the naive murine antibody repertoire using unamplified high-throughput sequencing
Characterization of the naive murine antibody repertoire using unamplified high-throughput sequencing
Cellular & Tissue Engineering
Abstractive Summary
Study examining characterization of the naive murine antibody repertoire using. Space travel significantly compromises immune function through impaired T-cell activity, reduced NK cell function, and inflammatory cytokine dysregulation. Latent viruses frequently reactivate, and wound healing is delayed. These findings raise concerns about infection risk and vaccine effectiveness during long missions.
Extractive Summary
Study examining characterization of the naive murine antibody repertoire using. Spaceflight induced significant immune system dysregulation. T-cell function was impaired with reduced proliferation capacity. Natural killer cell activity decreased substantially. Cytokine profiles shifted toward pro-inflammatory states. Latent viral reactivation occurred in 60% of crew members. Wound healing processes were delayed. Vaccine efficacy may be compromised in space environments.
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Keywords
characterization, naive, murine, antibody, repertoire, using, unamplified, high, throughput, sequencing, cell, study, examining, characterization, naive, murine, antibody, repertoire, using, spaceflight, function, cell, study, examining, characterization, naive, murine, antibody, repertoire, using
Abstractive Keywords
function, cell, study, examining, characterization, naive, murine, antibody, repertoire, using
Extractive Keywords
cell, study, examining, characterization, naive, murine, antibody, repertoire, using, spaceflight
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