Cytoskeleton structure and total methylation of mouse cardiac and lung tissue during space flight.
Cellular & Tissue Engineering
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Study examining cytoskeleton structure and total methylation of mouse cardiac. Spaceflight causes significant cardiovascular deconditioning, including cardiac atrophy, reduced blood volume, and vascular changes. Most crew members develop orthostatic intolerance post-flight, with impaired cerebral blood flow regulation. Arterial stiffness increases, presenting challenges for re-adaptation to gravity.
Study examining cytoskeleton structure and total methylation of mouse cardiac. Cardiovascular deconditioning was observed with reduced cardiac mass and altered vascular function. Blood volume decreased by 10-15% within first weeks. Orthostatic intolerance developed in 70% of crew post-flight. Carotid artery stiffness increased during flight. Cardiac atrophy affected left ventricular mass. Cerebral blood flow regulation was impaired upon return to gravity.