Articles
●
Cellular & Tissue Engineering
●
Detection of Target Genes for Drug Repurposing to Treat Skeletal Muscle Atrophy in Mice Flown in Spaceflight
Detection of Target Genes for Drug Repurposing to Treat Skeletal Muscle Atrophy in Mice Flown in Spaceflight
Cellular & Tissue Engineering
Abstractive Summary
Study examining detection of target genes for drug repurposing to. Extended spaceflight causes significant bone loss through increased osteoclast activity and decreased osteoblast function. Calcium metabolism is disrupted, with elevated resorption markers. While countermeasures provide partial protection, complete recovery requires 12-18 months post-flight, presenting major challenges for long-duration missions.
Extractive Summary
Study examining detection of target genes for drug repurposing to. Bone mineral density decreased significantly during extended spaceflight missions. Osteoclast activity increased while osteoblast function declined. Calcium metabolism was disrupted with elevated urinary calcium excretion. Bone resorption markers TRAP and CTX-1 were significantly elevated. Mechanical loading countermeasures showed partial effectiveness. Recovery of bone density post-flight required 12-18 months on average.
243
Keywords
detection, target, genes, drug, repurposing, treat, skeletal, muscle, atrophy, mice, bone, density, significantly, calcium, elevated, study, examining, detection, target, genes, study, examining, detection, target, genes, drug, repurposing, extended, spaceflight, causes
Abstractive Keywords
study, examining, detection, target, genes, drug, repurposing, extended, spaceflight, causes
Extractive Keywords
bone, density, significantly, calcium, elevated, study, examining, detection, target, genes
Topic Match Articles