Discoveries from human stem cell research in space that are relevant to advancing cellular therapies on Earth.
Unclassified
space, adaptation, conditions, novel, bacterial, species, isolated, from, international, station, genes, expression, study, examining, adaptation, space, conditions, novel, bacterial, species, changes, long, study, examining, adaptation, space, conditions, novel, bacterial, species
space, adaptation, conditions, novel, bacterial, species, isolated, from, international, station
changes, long, study, examining, adaptation, space, conditions, novel, bacterial, species
genes, expression, study, examining, adaptation, space, conditions, novel, bacterial, species
Study examining adaptation to space conditions of novel bacterial species. Spaceflight triggers widespread changes in gene expression affecting stress responses, DNA repair, and mitochondrial function. Epigenetic modifications occur, with some changes persisting long after return. Understanding these molecular adaptations is fundamental to developing effective countermeasures for long-duration missions.
Study examining adaptation to space conditions of novel bacterial species. Genome-wide expression analysis revealed thousands of differentially expressed genes. Stress response pathways were universally upregulated. DNA repair genes showed increased expression. Mitochondrial genes were downregulated substantially. Epigenetic modifications included altered methylation patterns. Some changes persisted months after return to Earth. Cell cycle regulation genes were significantly affected.