Draft genome sequences of biosafety level 2 opportunistic pathogens isolated from the environmental surfaces of the International Space Station.
Neurological & Sensory System Changes
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Study examining draft genome sequences of two aspergillus fumigatus strains,. Spaceflight triggers widespread changes in gene expression affecting stress responses, DNA repair, and mitochondrial function. Epigenetic modifications occur, with some changes persisting long after return. Understanding these molecular adaptations is fundamental to developing effective countermeasures for long-duration missions.
Study examining draft genome sequences of two aspergillus fumigatus strains,. Genome-wide expression analysis revealed thousands of differentially expressed genes. Stress response pathways were universally upregulated. DNA repair genes showed increased expression. Mitochondrial genes were downregulated substantially. Epigenetic modifications included altered methylation patterns. Some changes persisted months after return to Earth. Cell cycle regulation genes were significantly affected.