Articles
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Cellular & Tissue Engineering
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Focal enhancement of the skeleton to exercise correlates to mesenchymal stem cell responsivity rather than peak external forces.
Focal enhancement of the skeleton to exercise correlates to mesenchymal stem cell responsivity rather than peak external forces.
Cellular & Tissue Engineering
Abstractive Summary
Study examining focal enhancement of the skeleton to exercise correlates. Spaceflight triggers widespread changes in gene expression affecting stress responses, DNA repair, and mitochondrial function. Epigenetic modifications occur, with some changes persisting long after return. Understanding these molecular adaptations is fundamental to developing effective countermeasures for long-duration missions.
Extractive Summary
Study examining focal enhancement of the skeleton to exercise correlates. Genome-wide expression analysis revealed thousands of differentially expressed genes. Stress response pathways were universally upregulated. DNA repair genes showed increased expression. Mitochondrial genes were downregulated substantially. Epigenetic modifications included altered methylation patterns. Some changes persisted months after return to Earth. Cell cycle regulation genes were significantly affected.
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Keywords
focal, enhancement, skeleton, exercise, correlates, mesenchymal, stem, cell, responsivity, rather, genes, expression, study, examining, focal, enhancement, skeleton, exercise, correlates, genome, changes, long, study, examining, focal, enhancement, skeleton, exercise, correlates, spaceflight
Abstractive Keywords
changes, long, study, examining, focal, enhancement, skeleton, exercise, correlates, spaceflight
Extractive Keywords
genes, expression, study, examining, focal, enhancement, skeleton, exercise, correlates, genome
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