Articles
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Neurological & Sensory System Changes
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Hypothalamic leptin gene therapy reduces body weight without accelerating age-related bone loss
Hypothalamic leptin gene therapy reduces body weight without accelerating age-related bone loss
Neurological & Sensory System Changes
Abstractive Summary
Study examining morbid obesity attenuates the skeletal abnormalities associated with. Extended spaceflight causes significant bone loss through increased osteoclast activity and decreased osteoblast function. Calcium metabolism is disrupted, with elevated resorption markers. While countermeasures provide partial protection, complete recovery requires 12-18 months post-flight, presenting major challenges for long-duration missions.
Extractive Summary
Study examining morbid obesity attenuates the skeletal abnormalities associated with. Bone mineral density decreased significantly during extended spaceflight missions. Osteoclast activity increased while osteoblast function declined. Calcium metabolism was disrupted with elevated urinary calcium excretion. Bone resorption markers TRAP and CTX-1 were significantly elevated. Mechanical loading countermeasures showed partial effectiveness. Recovery of bone density post-flight required 12-18 months on average.
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Keywords
morbid, obesity, attenuates, skeletal, abnormalities, associated, leptin, deficiency, mice, bone, density, significantly, calcium, elevated, study, examining, morbid, obesity, attenuates, study, examining, morbid, obesity, attenuates, skeletal, abnormalities, associated, extended, spaceflight
Abstractive Keywords
study, examining, morbid, obesity, attenuates, skeletal, abnormalities, associated, extended, spaceflight
Extractive Keywords
bone, density, significantly, calcium, elevated, study, examining, morbid, obesity, attenuates
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