Increasing the number of unloading/reambulation cycles does not adversely impac body composition and lumbar bone mineral density but reduces tissue sensitivity
Cellular & Tissue Engineering
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Study examining increasing the number of unloading/reambulation cycles does not. Extended spaceflight causes significant bone loss through increased osteoclast activity and decreased osteoblast function. Calcium metabolism is disrupted, with elevated resorption markers. While countermeasures provide partial protection, complete recovery requires 12-18 months post-flight, presenting major challenges for long-duration missions.
Study examining increasing the number of unloading/reambulation cycles does not. Bone mineral density decreased significantly during extended spaceflight missions. Osteoclast activity increased while osteoblast function declined. Calcium metabolism was disrupted with elevated urinary calcium excretion. Bone resorption markers TRAP and CTX-1 were significantly elevated. Mechanical loading countermeasures showed partial effectiveness. Recovery of bone density post-flight required 12-18 months on average.