Articles
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Neurological & Sensory System Changes
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Leptin stimulates bone formation in ob/ob mice at doses having minimal impact on energy metabolism.
Leptin stimulates bone formation in ob/ob mice at doses having minimal impact on energy metabolism.
Neurological & Sensory System Changes
Abstractive Summary
Study examining effects of hypothalamic leptin gene therapy on osteopetrosis. Spaceflight triggers widespread changes in gene expression affecting stress responses, DNA repair, and mitochondrial function. Epigenetic modifications occur, with some changes persisting long after return. Understanding these molecular adaptations is fundamental to developing effective countermeasures for long-duration missions.
Extractive Summary
Study examining effects of hypothalamic leptin gene therapy on osteopetrosis. Genome-wide expression analysis revealed thousands of differentially expressed genes. Stress response pathways were universally upregulated. DNA repair genes showed increased expression. Mitochondrial genes were downregulated substantially. Epigenetic modifications included altered methylation patterns. Some changes persisted months after return to Earth. Cell cycle regulation genes were significantly affected.
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Keywords
leptin, effects, hypothalamic, gene, therapy, osteopetrosis, deficient, mice, genes, expression, study, examining, effects, hypothalamic, leptin, gene, therapy, osteopetrosis, gene, changes, long, study, examining, effects, hypothalamic, leptin, therapy, osteopetrosis
Abstractive Keywords
gene, changes, long, study, examining, effects, hypothalamic, leptin, therapy, osteopetrosis
Extractive Keywords
genes, expression, study, examining, effects, hypothalamic, leptin, gene, therapy, osteopetrosis
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