Articles
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Neurological & Sensory System Changes
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Metabolic Coupling Between Bone Marrow Adipose Tissue and Hematopoiesis
Metabolic Coupling Between Bone Marrow Adipose Tissue and Hematopoiesis
Neurological & Sensory System Changes
Abstractive Summary
Study examining bone marrow adipose tissue deficiency increases disuse-induced bone. Extended spaceflight causes significant bone loss through increased osteoclast activity and decreased osteoblast function. Calcium metabolism is disrupted, with elevated resorption markers. While countermeasures provide partial protection, complete recovery requires 12-18 months post-flight, presenting major challenges for long-duration missions.
Extractive Summary
Study examining bone marrow adipose tissue deficiency increases disuse-induced bone. Bone mineral density decreased significantly during extended spaceflight missions. Osteoclast activity increased while osteoblast function declined. Calcium metabolism was disrupted with elevated urinary calcium excretion. Bone resorption markers TRAP and CTX-1 were significantly elevated. Mechanical loading countermeasures showed partial effectiveness. Recovery of bone density post-flight required 12-18 months on average.
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Keywords
bone, marrow, adipose, tissue, deficiency, increases, disuse, induced, loss, male, bone, density, significantly, calcium, elevated, study, examining, marrow, adipose, tissue, bone, study, examining, marrow, adipose, tissue, deficiency, increases, disuse, induced
Abstractive Keywords
bone, study, examining, marrow, adipose, tissue, deficiency, increases, disuse, induced
Extractive Keywords
bone, density, significantly, calcium, elevated, study, examining, marrow, adipose, tissue
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