Articles
●
Neurological & Sensory System Changes
●
Morbid obesity attenuates the skeletal abnormalities associated with leptin deficiency in mice
Morbid obesity attenuates the skeletal abnormalities associated with leptin deficiency in mice
Neurological & Sensory System Changes
Abstractive Summary
Study examining acute exposure to high dose gamma-radiation results in. Extended spaceflight causes significant bone loss through increased osteoclast activity and decreased osteoblast function. Calcium metabolism is disrupted, with elevated resorption markers. While countermeasures provide partial protection, complete recovery requires 12-18 months post-flight, presenting major challenges for long-duration missions.
Extractive Summary
Study examining acute exposure to high dose gamma-radiation results in. Bone mineral density decreased significantly during extended spaceflight missions. Osteoclast activity increased while osteoblast function declined. Calcium metabolism was disrupted with elevated urinary calcium excretion. Bone resorption markers TRAP and CTX-1 were significantly elevated. Mechanical loading countermeasures showed partial effectiveness. Recovery of bone density post-flight required 12-18 months on average.
464
Keywords
acute, exposure, high, dose, gamma, radiation, results, transient, activation, bone, bone, density, significantly, calcium, elevated, study, examining, acute, exposure, high, study, examining, acute, exposure, high, dose, gamma, radiation, results, extended
Abstractive Keywords
study, examining, acute, exposure, high, dose, gamma, radiation, results, extended
Extractive Keywords
bone, density, significantly, calcium, elevated, study, examining, acute, exposure, high
Topic Match Articles