Articles
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Cellular & Tissue Engineering
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Muscle atrophy phenotype gene expression during spaceflight is linked to a metabolic crosstalk in both the liver and the muscle in mice.
Muscle atrophy phenotype gene expression during spaceflight is linked to a metabolic crosstalk in both the liver and the muscle in mice.
Cellular & Tissue Engineering
Abstractive Summary
Study examining muscle atrophy phenotype gene expression during spaceflight is. Microgravity causes rapid skeletal muscle atrophy, particularly affecting slow-twitch fibers. Protein synthesis decreases while breakdown increases, and muscle phenotype shifts toward faster fibers. Despite exercise countermeasures, significant muscle loss occurs, along with mitochondrial dysfunction and reduced oxidative capacity.
Extractive Summary
Study examining muscle atrophy phenotype gene expression during spaceflight is. Skeletal muscle atrophy progressed rapidly in microgravity with 10-20% mass loss within first month. Type I slow-twitch fibers were preferentially affected. Protein synthesis decreased while proteolytic pathways upregulated. Myosin heavy chain isoforms shifted toward faster phenotypes. Exercise countermeasures attenuated but did not prevent muscle loss. Mitochondrial function declined with reduced oxidative capacity.
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Keywords
muscle, atrophy, phenotype, gene, expression, during, spaceflight, linked, metabolic, crosstalk, muscle, atrophy, loss, study, examining, phenotype, gene, expression, during, spaceflight, muscle, atrophy, phenotype, fibers, study, examining, gene, expression, during, spaceflight
Abstractive Keywords
muscle, atrophy, phenotype, fibers, study, examining, gene, expression, during, spaceflight
Extractive Keywords
muscle, atrophy, loss, study, examining, phenotype, gene, expression, during, spaceflight
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