Articles
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Cellular & Tissue Engineering
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Partial reductions in mechanical loading yield proportional changes in bone density, bone architecture, and muscle mass
Partial reductions in mechanical loading yield proportional changes in bone density, bone architecture, and muscle mass
Cellular & Tissue Engineering
Abstractive Summary
Study examining partial reductions in mechanical loading yield proportional changes. Extended spaceflight causes significant bone loss through increased osteoclast activity and decreased osteoblast function. Calcium metabolism is disrupted, with elevated resorption markers. While countermeasures provide partial protection, complete recovery requires 12-18 months post-flight, presenting major challenges for long-duration missions.
Extractive Summary
Study examining partial reductions in mechanical loading yield proportional changes. Bone mineral density decreased significantly during extended spaceflight missions. Osteoclast activity increased while osteoblast function declined. Calcium metabolism was disrupted with elevated urinary calcium excretion. Bone resorption markers TRAP and CTX-1 were significantly elevated. Mechanical loading countermeasures showed partial effectiveness. Recovery of bone density post-flight required 12-18 months on average.
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Keywords
bone, partial, reductions, mechanical, loading, yield, proportional, changes, density, architecture, bone, partial, mechanical, loading, density, significantly, calcium, elevated, study, examining, partial, study, examining, reductions, mechanical, loading, yield, proportional, changes, extended
Abstractive Keywords
partial, study, examining, reductions, mechanical, loading, yield, proportional, changes, extended
Extractive Keywords
bone, partial, mechanical, loading, density, significantly, calcium, elevated, study, examining
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