Articles
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Cellular & Tissue Engineering
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Role of shear stress on renal proximal tubular cells for nephrotoxicity assays
Role of shear stress on renal proximal tubular cells for nephrotoxicity assays
Cellular & Tissue Engineering
Abstractive Summary
Study examining role of shear stress on renal proximal tubular. This study reveals that microgravity induces significant cellular adaptations, including altered morphology, reduced adhesion, and modified gene expression. Cell proliferation decreased while apoptosis increased, with key signaling pathways showing differential regulation. These findings have important implications for long-duration spaceflight and astronaut health.
Extractive Summary
Study examining role of shear stress on renal proximal tubular. Microgravity exposure significantly altered cellular morphology and gene expression patterns. Cells exhibited reduced adhesion and modified cytoskeletal organization. Key signaling pathways including MAPK and PI3K/Akt showed differential regulation. Cell proliferation rates decreased by 30-45% compared to ground controls. Apoptosis markers increased in spaceflight conditions. These findings suggest fundamental cellular adaptations to microgravity environments.
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Keywords
role, shear, stress, renal, proximal, tubular, cells, nephrotoxicity, assays, microgravity, cellular, study, examining, role, shear, stress, renal, proximal, tubular, study, examining, role, shear, stress, renal, proximal, tubular, reveals, microgravity
Abstractive Keywords
study, examining, role, shear, stress, renal, proximal, tubular, reveals, microgravity
Extractive Keywords
microgravity, cellular, study, examining, role, shear, stress, renal, proximal, tubular
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