Articles
●
Neurological & Sensory System Changes
●
Room temperature housing results in premature cancellous bone loss in growing female mice: implications for the mouse as a preclinical model for age-related bone loss.
Room temperature housing results in premature cancellous bone loss in growing female mice: implications for the mouse as a preclinical model for age-related bone loss.
Neurological & Sensory System Changes
Abstractive Summary
Study examining hypothalamic leptin gene therapy reduces bone marrow adiposity. Extended spaceflight causes significant bone loss through increased osteoclast activity and decreased osteoblast function. Calcium metabolism is disrupted, with elevated resorption markers. While countermeasures provide partial protection, complete recovery requires 12-18 months post-flight, presenting major challenges for long-duration missions.
Extractive Summary
Study examining hypothalamic leptin gene therapy reduces bone marrow adiposity. Bone mineral density decreased significantly during extended spaceflight missions. Osteoclast activity increased while osteoblast function declined. Calcium metabolism was disrupted with elevated urinary calcium excretion. Bone resorption markers TRAP and CTX-1 were significantly elevated. Mechanical loading countermeasures showed partial effectiveness. Recovery of bone density post-flight required 12-18 months on average.
467
Keywords
hypothalamic, leptin, gene, therapy, reduces, bone, marrow, adiposity, mice, regular, bone, density, significantly, calcium, elevated, study, examining, hypothalamic, leptin, gene, bone, study, examining, hypothalamic, leptin, gene, therapy, reduces, marrow, adiposity
Abstractive Keywords
bone, study, examining, hypothalamic, leptin, gene, therapy, reduces, marrow, adiposity
Extractive Keywords
bone, density, significantly, calcium, elevated, study, examining, hypothalamic, leptin, gene
Topic Match Articles