Articles
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Cellular & Tissue Engineering
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Simultaneous exposure of cultured human lymphoblastic cells to simulated microgravity and radiation increases chromosome aberrations
Simultaneous exposure of cultured human lymphoblastic cells to simulated microgravity and radiation increases chromosome aberrations
Cellular & Tissue Engineering
Abstractive Summary
Study examining simultaneous exposure of cultured human lymphoblastic cells to. Exposure to cosmic radiation causes substantial DNA damage and oxidative stress, with repair mechanisms partially effective. Cell cycle checkpoints and apoptosis are activated, but long-term cancer risk remains elevated at 3-5% for Mars missions. Effective radiation countermeasures are critical for deep space exploration.
Extractive Summary
Study examining simultaneous exposure of cultured human lymphoblastic cells to. Cosmic radiation exposure caused significant DNA damage with increased double-strand breaks. Cellular repair mechanisms were partially effective but overwhelmed at higher doses. Oxidative stress markers were elevated substantially. Cell cycle checkpoints showed prolonged activation. Apoptosis rates increased dose-dependently. Long-term cancer risk estimates ranged from 3-5% for Mars missions.
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Keywords
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Abstractive Keywords
exposure, radiation, effective, study, examining, simultaneous, cultured, human, lymphoblastic, cells
Extractive Keywords
exposure, increased, study, examining, simultaneous, cultured, human, lymphoblastic, cells, cosmic
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