Small changes in thermoregulation influence cancellous bone turnover balance in distal femur metaphysis in growing female mice
Neurological & Sensory System Changes
leptin, environmental, temperature, determinants, bone, marrow, adiposity, female, mice, bone, density, significantly, calcium, elevated, study, examining, leptin, environmental, temperature, bone, study, examining, leptin, environmental, temperature, determinants, extended, spaceflight, causes
leptin, environmental, temperature, determinants, bone, marrow, adiposity, female, mice
bone, study, examining, leptin, environmental, temperature, determinants, extended, spaceflight, causes
bone, density, significantly, calcium, elevated, study, examining, leptin, environmental, temperature
Study examining leptin and environmental temperature as determinants of bone. Extended spaceflight causes significant bone loss through increased osteoclast activity and decreased osteoblast function. Calcium metabolism is disrupted, with elevated resorption markers. While countermeasures provide partial protection, complete recovery requires 12-18 months post-flight, presenting major challenges for long-duration missions.
Study examining leptin and environmental temperature as determinants of bone. Bone mineral density decreased significantly during extended spaceflight missions. Osteoclast activity increased while osteoblast function declined. Calcium metabolism was disrupted with elevated urinary calcium excretion. Bone resorption markers TRAP and CTX-1 were significantly elevated. Mechanical loading countermeasures showed partial effectiveness. Recovery of bone density post-flight required 12-18 months on average.