Articles
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Neurological & Sensory System Changes
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Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adult Caenorhabditis elegans
Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adult Caenorhabditis elegans
Neurological & Sensory System Changes
Abstractive Summary
Study examining nemalife chip: a micropillar-based microfluidic culture device optimized. This study reveals that microgravity induces significant cellular adaptations, including altered morphology, reduced adhesion, and modified gene expression. Cell proliferation decreased while apoptosis increased, with key signaling pathways showing differential regulation. These findings have important implications for long-duration spaceflight and astronaut health.
Extractive Summary
Study examining nemalife chip: a micropillar-based microfluidic culture device optimized. Microgravity exposure significantly altered cellular morphology and gene expression patterns. Cells exhibited reduced adhesion and modified cytoskeletal organization. Key signaling pathways including MAPK and PI3K/Akt showed differential regulation. Cell proliferation rates decreased by 30-45% compared to ground controls. Apoptosis markers increased in spaceflight conditions. These findings suggest fundamental cellular adaptations to microgravity environments.
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Keywords
nemalife, chip, micropillar, based, microfluidic, culture, device, optimized, aging, studies, microgravity, cellular, study, examining, nemalife, chip, micropillar, based, microfluidic, culture, study, examining, nemalife, chip, micropillar, based, microfluidic, culture, device, optimized
Abstractive Keywords
study, examining, nemalife, chip, micropillar, based, microfluidic, culture, device, optimized
Extractive Keywords
microgravity, cellular, study, examining, nemalife, chip, micropillar, based, microfluidic, culture
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